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Effects of Salmon Calcitonin on Patients With Atypical (Idiopathic) Facial Pain: A Randomized Controlled Trial
1Faculty of Dentistry, Craniofacial Pain Research Unit, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
2Oenter for Neurological Sciences Research,University of Montreal, Montreal, Quebec, Oanada
3Craniofacial Pam Research Unit, Mount Sinsi Hospital, University of Toronto, Toronto, Ontario, Canada
4Department of Neurology, Faculty of Medicine, Mount Sinsi Hospital, University of Toronto, Toronto, Ontario, Canada
5Faculty of Dentistry, Medical Research Council Oroup in Periodontal Physiology, Crsniofacisl Pain Research Unit, Faculty of Medicine, Mount Sinsi Hospital, University of Toronto, Toronto, Ontario
*Corresponding Author(s): Howard O. Tenenbaum E-mail:
The analgesic properties of salmon calcitonin for the treatment of atypical facial pain (AFP) were investigated. An initial open-label trial of salmon calcitonin in subjects with refractory AFP was followed with a randomized, double-blind, placebo-controlled crossover trial of salmon calcitonin in the management of AFP. Salmon calcitonin (100 IU in 1 mL saline) was administered in an open-label fashion to 13 subjects with refractory AFP five times per week for 6 weeks. In the subsequent randomized investigation, salmon calcitonin (100 IU in 1 mL saline) or placebo (1 mL saline) was delivered three times per week for 3 weeks, with a 1-week washout prior to crossover. The percentage of subjects dropping out (57%) exceeded that reported in other pain studies using calcitonin. Therefore, it was imperative to halt the study for ethical reasons. There was no difference in outcome measures (P > .05) in subjects administered either active drug or placebo, and a high incidence of side effects led to dropout in subjects taking salmon calcitonin. Although salmon calcitonin may have analgesic properties, it is not efficacious for AFP, largely because of the side effects.
atypical facial pain; calcitonin; randomized trial
Howard O. Tenenbaum,Gordon Schwartz,Marilyn Galonski,Allan Gordon,Maureen Shandling,David Mock,Howard C. Tenenfaaum. Effects of Salmon Calcitonin on Patients With Atypical (Idiopathic) Facial Pain: A Randomized Controlled Trial. Journal of Oral & Facial Pain and Headache. 1996. 10(4);306-315.
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