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Effects of Adjuvant on Neuropeptide-Like Immunoreactivity in the Temporomandibular Joint and Trigeminal Ganglia
1Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden
2Center for Clinical Oral Science, School of Dentistry, Karolinska Institute, Huddinge, Sweden
3Department of Clinical Chemistry, University Hospital, Lind ko ping, Svi/eden
4Department of Rehabilitation and Physical Medicine, Karolinska Hospital, Stockholm, Sweden
*Corresponding Author(s): Joakim Carleson E-mail:
To study the role of the nervous system in temporomandibular joint arthritis, substance P-, calcitonin gene-related peptide-, and neuropeptide Y-like immunoreactivity in the trigeminal ganglia and temporomandibular joint of rats was examined. Arthritis was induced in female Lewis rats through bilateral injection of a suspension of heat-killed Mycobacterium butyricum in paraffin oil into the temporomandibular joint. Control rats received paraffin oil via the same route. Tissues were collected for neuropeptide extraction 28 days after injection and analyzed by radioimmunoassay and reverse-phase high-performance liquid chromatography. Calcitonin gene-related peptide was significantly increased in the arthritic trigeminal ganglia. Substance P, calcitonin gene-related peptide, and neuropeptide Y in the arthritic temporomandibular joint were significantly increased as compared to controls. The results of this study show that sensory and sympathetic neuropeptides may possibly be associated with the development of arthritis in the temporomandibular joint of rats.
adjuvant arthritis; calcitonin gene-related peptide; immunoreactivity; neuropeptide Y; radioimmunoassay, substance P; temporomandibular joint; trigeminal ganglia
Joakim Carleson,Indre Bileviciute,Elvar Theodorsson,Bjorn Appelgren,Anna Appelgren,Nancy Yousef,Sigvard Kopp,Thomas Lundeherg. Effects of Adjuvant on Neuropeptide-Like Immunoreactivity in the Temporomandibular Joint and Trigeminal Ganglia. Journal of Oral & Facial Pain and Headache. 1997. 11(3);195-199.
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