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TMJ Pain in Relation to Circulating N europeptide Y, Serotonin, and Interleukin-1 β in Rheumatoid Arthritis
1Department of Clinical Oral Physiology, Karolinska lnstitutet, Stockholm, Sweden
2Department of Pharmacology and Physiology, Karolinska lnstitutet, Stockholm, Sweden
3Department of Clinical Chemistry, University of Linkoping, Linkoping, Sweden
*Corresponding Author(s): Per Alstergren E-mail:
Aims: The aim of this study was to test the hypothesis that temporomandibular joint (TMJ) pain is influenced by circulating levels of neuropeptide Y, serotonin, and interleukin-1 beta in rheumatoid arthritis.
Methods: Forty-three seropositive (RF+) or seronegative (RF-) rheumatoid arthritis patients and 24 healthy individuals were included in the study.
Results: High serum concentrations of serotonin were associated with low TMJ pressure pain thresholds and pain during mandibular movement in the RF+ patients. The results of this study do not support a relationship between circulating neuropeptide Y or interleukin-1 beta and TMJ pain. The RF+ patients had higher C-reactive protein levels and erythrocyte sedimentation rates than the RF- patients. There were also higher plasma levels of interleukin-1 beta in the RF+ patients than in the healthy individuals. Plasma levels of neuropeptide Y in the RF- patients were higher than in the healthy individuals.
Conclusion: This study indicates that the serum concentration of serotonin is associated with TMJ allodynia in seropositive rheumatoid arthritis.
pain; serotonin; interleukin-1B; rheumatoid arthritis; temporomandibular joint
Per Alstergren,Malin Ernberg,Sigvard Kopp,Tomas Lundeberg,Elvar Theodorsson. TMJ Pain in Relation to Circulating N europeptide Y, Serotonin, and Interleukin-1 β in Rheumatoid Arthritis. Journal of Oral & Facial Pain and Headache. 1999. 13(1);49-55.
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