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Original Research

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Pain, Allodynia, and Serum Serotonin Level in Orofacial Pain of Muscular Origin

  • Malin Emberg 1,*,
  • Britt Hedenberg-Magnusson1
  • Per Alstergren1
  • Thomas Lundeberg2
  • Sigvard Kopp1

1Department of Clinical Oral Physiology, Karolinska Institute, Stockholm, Sweden

2Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden

DOI: 10.11607/jofph.1356 Vol.13,Issue 1,March 1999 pp.56-62

Published: 30 March 1999

*Corresponding Author(s): Malin Emberg E-mail: malin.emberg@ofa.ki.se

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Abstract

Aims: This study was conducted to investigate the serum level of serotonin (S-5-HT) in patients with temporomandibular disorders (TMD) of muscular origin, i.e., localized myalgia, and to compare it to that found in healthy individuals and patients with fibromyalgia. A second aim was to investigate the association between S-5-HT and pain parameters.

Methods: Twenty patients with localized myalgia participated in the study. Twenty age- and gender-matched healthy individuals and twenty patients with fibromyalgia served as controls. The participants were examined clinically as to the condition of the temporomandibular region and S-5-HT.

Results: The levels of S-5-HT did not differ significantly between the groups. However, in patients with localized myalgia there was a negative correlation between S-5-HT and tenderness of the temporomandibular muscles.

Conclusion: The results of this study indicate that allodynia of orofacial muscles in patients with TMD is significantly related to S-5-HT concentration.

Keywords

fibromyalgia; allodynia; local myalgia; serotonin; temporomandibular disorders

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Malin Emberg ,Britt Hedenberg-Magnusson,Per Alstergren,Thomas Lundeberg,Sigvard Kopp. Pain, Allodynia, and Serum Serotonin Level in Orofacial Pain of Muscular Origin. Journal of Oral & Facial Pain and Headache. 1999. 13(1);56-62.

URL:

https://www.jofph.com/articles/10.11607/jofph.1356

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