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Trazodone in Burning Mouth Pain: A Placebo-Controlled, Double-Blind Study

  • Tuulikki Tammiala-Salonen1
  • Heli Forssell 2,*,

1Institute of Dentistry, Turku University, Turku, Finland

2Department of Oral Diseases, Turku University Central Hospital, Turku, Finland

DOI: 10.11607/jofph.1383 Vol.13,Issue 2,June 1999 pp.83-88

Published: 30 June 1999

*Corresponding Author(s): Heli Forssell E-mail: heli.forssell@utu.fi

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Abstract

Aims: An 8-week parallel, placebo-controlled, double-blind trial evaluated the efficacy of the antidepressant trazodone in the treatment of chronic burning mouth pain.

Methods: Thirty-seven carefully selected women aged 39 to 71 (mean 58.6 years) were randomized to receive either 200 mg of trazodone or a placebo in a similar manner. Pain and pain-related symptoms were evaluated on a visual analogue scale and other measures at 0, 2, 4, and 8 weeks.

Results: There were no significant differences between the groups in treatment effects for pain or pain-related symptoms. Seven patients in the trazodone group and 2 in the placebo group failed to complete the trial because of side effects. The most common side effects were dizziness and drowsiness.

Conclusion: In this controlled trial, trazodone failed to relieve burning mouth pain.

Keywords

burning mouth; oral mucosal pain; chronie pain; trazodone; antidepressants

Cite and Share

Tuulikki Tammiala-Salonen,Heli Forssell . Trazodone in Burning Mouth Pain: A Placebo-Controlled, Double-Blind Study. Journal of Oral & Facial Pain and Headache. 1999. 13(2);83-88.

URL:

https://www.jofph.com/articles/10.11607/jofph.1383

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