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Original Research

Open Access

Reports of SSRI-Associated Bruxism in the Family Physician’s Office

  • Frank Lobbezoo1,*,
  • Ronald J. A. van Denderen1
  • Johannes G. C. Verheij1
  • Machiel Naeije1

1Department of Oral Function, Academic Centre for Dentistry Amsterdam (ACTA), Amsterdam, The Netherlands

DOI: 10.11607/jofph.15405 Vol.15,Issue 4,December 2001 pp.340-346

Published: 30 December 2001

*Corresponding Author(s): Frank Lobbezoo E-mail: f.lobbezoo@acta.nl

Abstract

Aims: Recently, the use of selective serotonin reuptake inhibitors (SSRIs) has been associated with the occurrence or worsening of bruxism. The aim of this study was to obtain a first indication of the prevalence of SSRI-associated bruxism reported to family physicians, the main prescribers of SSRIs. Methods: A questionnaire, with questions about prescription rate, already registered adverse reactions, and bruxism-related side effects of 4 different types of SSRIs, was sent to all family physicians in greater Amsterdam (n = 391). Results: With a response rate of 42.5%, frequent observations of already registered side effects were found. In addition, 5 family physicians (3.2%) reported the occurrence of bruxism in relation to the use of SSRIs. Conclusion: The use of SSRIs might be associated with the occurrence of bruxism. A case report is provided that corroborates this suggestion.


Keywords

bruxism; serotonin reuptake inhibitors; adverse drug reaction reporting systems; questionnaire; case report

Cite and Share

Frank Lobbezoo,Ronald J. A. van Denderen,Johannes G. C. Verheij,Machiel Naeije. Reports of SSRI-Associated Bruxism in the Family Physician’s Office. Journal of Oral & Facial Pain and Headache. 2001. 15(4);340-346.

References

1. Pranzatelli MR. Serotonergic drugs and movement disorders in humans. Drugs Today 1997;33:379–392.

2. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, ed 4. Washington, DC: American Psychiatric Association, 1994.

3. Van Ermen AMC, Ottervanger JP, Roisin T, Kurz X, Stricker BHC. Meldingen van vermoedelijke bijwerkingen van selectieve serotonine-heropnameremmers in België en Nederland. Ned Tijdschr Geneeskd 1996;140:1817–1820.

4. Spigset O. Adverse reactions of selective serotonin reuptake inhibitors. Reports from a spontaneous reporting system. Drug Safety 1999;20:277–287.

5. Lane RM. SSRI-induced extrapyramidal side effects and akathisia: Implications for treatment. J Psychopharmacol 1998;12:192–214.

6. Jansen Steur ENH. Increase of Parkinson disability after fluoxetine medication. Neurology 1993;43:211–213.

7. Jimenez-Jimenez FJ, Tejeiro J, Martinez-Junquera G, Cabrera-Valdivia F, Alarcon J, Garcia-Albea E. Parkinsonism exacerbated by paroxetine. Neurology 1994;44:2406.

8. Richard IH, Maughn A, Kurlan R. Do serotonin reuptake inhibitor antidepressants worsen Parkinson’s disease? A retrospective case series. Mov Disord 1999;14:155–157.

9. Bakshi R. Fluoxetine and restless legs syndrome. J Neurol Sci 1996;142:151–152.

10. Sanz-Fuentenebro FJ, Huidobro A, Tejadas-Rivas A. Restless legs syndrome and paroxetine. Acta Psychiatr Scand 1996;94:482–484.

11. Ellison JM, Stanziani P. SSRI-associated nocturnal bruxism in four patients. J Clin Psychiatry 1993;54:432–434.

12. Fitzgerald K, Healy D. Dystonias and dyskinesias of the jaw associated with the use of SSRIs. Human Psychopharmacol 1995;10:215–219.

13. Romanelli F, Adler DA, Bungay KM. Possible paroxetine-induced bruxism. Ann Pharmacother 1996;30:1246–1248.

14. Por CP, Watson L, Doucette D, Dolovich L. Sertraline-associated bruxism. Can J Clin Pharmacol 1996;3: 123–125.

15. Stein DJ, Van Greunen G, Niehaus D. Can bruxism respond to serotonin reuptake inhibitors? J Clin Psychiatry 1998;59:133.

16. Geneesmiddelenbulletin. Restless legs bij gebruik van paroxetine (Seroxat). Gebu Prikbord 1998;32:63–64.

17. Lavigne GJ, Goulet JP, Zucconi M, Morisson F, Lobbezoo

F. Sleep disorders and the dental patient. Oral Surg Oral Med Oral Pathol Radiol Endod 1999;88:257–272.

18. Lobbezoo F, Soucy JP, Montplaisir JY, Lavigne GJ. Striatal D2 receptor binding in sleep bruxism: A controlled study with iodine-123-iodobenzamide and single-photon emission-computed tomography. J Dent Res 1996;75:1804–1810.

19. Spilker B. Guide to Clinical Trials. New York: Raven Press, 1991.

20. Hulley SB, Cummings SR. Designing Clinical Research. Baltimore: Williams & Wilkins, 1988.

21. Arrindel WA, Ettema JHM. SCL-90. Handleiding bij een multidimensionele psychopathologie-indicator. Lisse: Swets en Zeitlinger, 1986.

22. Kapur S, Remington G. Serotonin-dopamine interaction and its relevance to schizophrenia. Am J Psychiatry 1996;153:466–476.

23. Lobbezoo F, Lavigne GJ, Tanguay R, Montplaisir JY. The effect of the catecholamine precursor L-dopa on sleep bruxism: A controlled clinical trial. Mov Disord 1997;12:73–78.

24. Lobbezoo F, Soucy JP, Hartman NG, Montplaisir JY, Lavigne GJ. Effects of the dopamine D2 receptor agonist bromocriptine on sleep bruxism: Report of two single-patient clinical trials. J Dent Res 1997;76:1611–1615.

25. Lambrechts P, Braem M, Vuylsteke-Wauters M, Van Herle G. Quantitative in vivo wear of human enamel. J Dent Res 1989;68:1752–1754.

26. Haddad P. The SSRI discontinuation syndrome. J Psychopharmacol 1998;12:305–313.

27. Bostwick JM, Jaffee MS. Buspirone as an antidote to SSRI-induced bruxism in 4 cases. J Clin Psychiatry 1999;60:857–860.

28. Jaffee MS, Bostwick JM. Buspirone as an antidote to venlafaxine-induced bruxism. Psychosomatics 2000;41: 535–536.

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