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Intraoral Administration of Botulinum Toxin for Continuous Dentoalveolar Neuropathic Pain: A Case Series
1740 S Limestone, Room E214, Kentucky Clinic, Lexington, KY 40536, USA
DOI: 10.11607/ofph.2031 Vol.33,Issue 2,June 2019 pp.160-164
Submitted: 20 July 2017 Accepted: 19 September 2018
Published: 30 June 2019
*Corresponding Author(s): Isabel Moreno-Hay E-mail: XXX
Aims: To lerability of intraoral administration of onabotulinum toxin A (BoNT/A) in patients suffering from intractable continuous dentoalveolar neuropathic pain. Methods: Eight patients (six women and two men) of ages ranging from 21 to 73 years (mean [standard deviation] 52.4 [16.1] years) suffering from continuous dentoalveolar pain for a mean duration of 5.8 (4.4) years received a submucosal injection of 10 to 25 units of BoNT/A into the vestibular mucosa surrounding the painful site. Pain intensity levels were recorded using a verbal rating scale (VRS). Safety and tolerability of BoNT/A were measured based on patient self-report, including any adverse effects reported by the patient at the injection site. Results: Five of eight patients reported positive pain reduction. In this group, mean pain intensity on a 0–10 VAS was 4.8 (2.2) at baseline and 2.6 (2.1) at postinjection. The analgesic effect was maximal between 7 and 14 days postinjection and lasted for 1 to 8 weeks before subsequently returning to the pre-injection levels. No adverse effects were reported at the injection sites. One patient noted transient partial hemi- facial paralysis. Conclusion: These results suggest the potential therapeutic benefit of BoNT/A in the management of continuous dentoalveolar neuropathic pain. Further investigations conducted via well-controlled studies in the area of orofacial pain are warranted. J Oral Facial Pain Headache 2019;33:160–164.
chronic pain;continuous neuropathic pain;dentoalveolar neuropathic pain;onabotulinum toxin A;orofacial pain
Isabel Moreno-Hay,Pratishtha Mishra,Jeffrey P. Okeson. Intraoral Administration of Botulinum Toxin for Continuous Dentoalveolar Neuropathic Pain: A Case Series. Journal of Oral & Facial Pain and Headache. 2019. 33(2);160-164.
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