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Systematic reviews

Open Access

Efficacy of laser therapy on primary burning mouth syndrome: a systematic review

  • Mehdi Khemiss1,2,3,*,
  • Nouha Dammak1,2,3
  • Oumaima Lajili1,2
  • Sinda Yacoub1,2,3
  • Mohamed Ben Khelifa1,2,3

1Department of Dental Medicine, Fattouma Bourguiba University Hospital of Monastir, 5000 Monastir, Tunisia

2Faculty of Dental Medicine, University of Monastir, 5000 Monastir, Tunisia

3Research Laboratory LR12SP10: Functional and Aesthetic Rehabilitation of the maxilla, Farhat HACHED University Hospital of Sousse, 4000 Sousse, Tunisia

DOI: 10.22514/jofph.2024.003 Vol.38,Issue 1,March 2024 pp.17-31

Submitted: 13 April 2023 Accepted: 22 November 2023

Published: 12 March 2024

*Corresponding Author(s): Mehdi Khemiss E-mail: mehdi.khemiss@rns.tn

Abstract

The objective of this study was to perform a systematic review of the literature to determine the overall efficacy of low-level laser therapy (LLLT) in managing burning mouth syndrome (BMS). A literature search was conducted through PubMed, Scopus, Web of Sciences, and Cochrane Central Register of Controlled Trials from their inception up to 28 March 2023. The search terms were defined by combining (Mesh Terms OR Key Words) from “Burning mouth syndrome” AND (Mesh Terms OR Key Words) from “Laser therapy”. Methodological quality assessment was performed using the Joanna Briggs Institute Critical appraisal tool, attributing scores from 1 to 13 to the selected studies. Literature search, study selection, and data extraction were carried out by two authors. Differences on issues were resolved by a third author, if required. The primary investigated outcome was reducing BMS pain. A total of 21 articles met the inclusion criteria. After assessing full-text articles for eligibility, 12 articles were excluded. Consequently, 9 articles were retained. A low score of bias was calculated in 66% of the included studies. Compared to placebo, a significant reduction in pain or burning sensation was reported in 5 studies. This significant reduction was still observed in the laser group at the two- and four-month follow-ups in 2 studies. LLLT could be beneficial for patients suffering from BMS. In order to get strong evidence for placebo use, future studies with standardized methodology and outcomes are required.


Keywords

Pain; Burning mouth syndrome; Stomatodynia; Trigeminal; Photobiomodulation


Cite and Share

Mehdi Khemiss,Nouha Dammak,Oumaima Lajili,Sinda Yacoub,Mohamed Ben Khelifa. Efficacy of laser therapy on primary burning mouth syndrome: a systematic review. Journal of Oral & Facial Pain and Headache. 2024. 38(1);17-31.

References

[1] Alamoudi N, Nadhreen A, Elkhodary H. Low-level laser therapy in dentistry: extra-oral applications. Nigerian Journal of Clinical Practice. 2019; 22: 1313.

[2] Yang H, Huang Y. Treatment of burning mouth syndrome with a low-level energy diode laser. Photomedicine and Laser Surgery. 2011; 29: 123–125.

[3] Gianfaldoni S, Tchernev G, Wollina U, Fioranelli M, Roccia MG, Gianfaldoni R, et al. An overview of laser in dermatology: the past, the present and … the future (?). Open Access Macedonian Journal of Medical Sciences. 2017; 5: 526–530.

[4] Hanna R, Dalvi S, Bensadoun RJ, Raber-Durlacher JE, Benedicenti S. Role of photobiomodulation therapy in neurological primary burning mouth syndrome. A systematic review and meta-analysis of human randomised controlled clinical trials. Pharmaceutics. 2021; 13: 1838.

[5] Moskvin SV. Low-level laser therapy in Russia: history, science and practice. Journal of Lasers in Medical Sciences. 2017; 8: 56–65.

[6] Parker S. Introduction, history of lasers and laser light production. British Dental Journal. 2007; 202: 21–31.

[7] Weichman JA, Johnson FM. Laser use in endodontics. Oral Surgery, Oral Medicine, Oral Pathology. 1971; 31: 416–420.

[8] Luke AM, Mathew S, Altawash MM, Madan BM. Lasers: a review with their applications in oral medicine. Journal of Lasers in Medical Sciences. 2019; 10: 324–329.

[9] Paschoal MAB, Belém FV, Clementino LC, Martins-Júnior PA. Application of lasers in dentistry: a bibliometric study of the top 100 most-cited papers. Brazilian Oral Research. 2022; 36: e104.

[10] Arjmand B, Khodadost M, Jahani Sherafat S, Rezaei Tavirani M, Ahmadi N, Hamzeloo Moghadam M, et al. Low-level laser therapy: potential and complications. Journal of Lasers in Medical Sciences. 2021; 12: e42.

[11] International classification of orofacial pain, 1st edition (ICOP). Cephalalgia. 2020; 4: 129–221.

[12] Aravindhan R, Vidyalakshmi S, Kumar MS, Satheesh C, Balasubramanium AM, Prasad VS. Burning mouth syndrome: a review on its diagnostic and therapeutic approach. Journal of Pharmacy and Bioallied Sciences. 2014; 6: S21–S25.

[13] Tan HL, Smith JG, Hoffmann J, Renton T. A systematic review of treatment for patients with burning mouth syndrome. Cephalalgia. 2022; 42: 128–161.

[14] Al-Maweri SA, Javed F, Kalakonda B, AlAizari NA, Al-Soneidar W, Al-Akwa A. Efficacy of low level laser therapy in the treatment of burning mouth syndrome: a systematic review. Photodiagnosis and Photodynamic Therapy. 2017; 17: 188–193.

[15] Matos AL, Silva PU, Paranhos LR, Santana IT, Matos FR. Efficacy of the laser at low intensity on primary burning oral syndrome: a systematic review. Medicina Oral, Patologia Oral y Cirugia Bucal. 2021; 26: e216–e225.

[16] Zhang W, Hu L, Zhao W, Yan Z. Effectiveness of photobiomodulation in the treatment of primary burning mouth syndrome—a systematic review and meta-analysis. Lasers in Medical Science. 2021; 36: 239–248.

[17] Camolesi GCV, Marichalar-Mendía X, Padín-Iruegas ME, Spanemberg JC, López-López J, Blanco-Carrión A, et al. Efficacy of photobiomodulation in reducing pain and improving the quality of life in patients with idiopathic burning mouth syndrome. A systematic review and meta-analysis. Lasers in Medical Science. 2022; 37: 2123–2133.

[18] Chen Sun W-WJ. Low-level laser treatment of burning mouth syndrome: a systematic review and meta-analysis. Frontiers of Oral and Maxillofacial Medicine. 2019; 1: 10.

[19] Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Journal of Clinical Epidemiology. 2021; 134: 178–189.

[20] Ma LL, Wang YY, Yang ZH, Huang D, Weng H, Zeng XT. Methodological quality (risk of bias) assessment tools for primary and secondary medical studies: what are they and which is better? Military Medical Research. 2020; 7: 7.

[21] Bardellini E, Amadori F, Conti G, Majorana A. Efficacy of the photobiomodulation therapy in the treatment of the burning mouth syndrome. Medicina Oral Patología Oral y Cirugia Bucal. 2019; 24: e787–e791.

[22] Kato IT, Pellegrini VD, Prates RA, Ribeiro MS, Wetter NU, Sugaya NN. Low-level laser therapy in burning mouth syndrome patients: a pilot study. Photomedicine and Laser Surgery. 2010; 28: 835–839.

[23] Arduino PG, Cafaro A, Garrone M, Gambino A, Cabras M, Romagnoli E, et al. A randomized pilot study to assess the safety and the value of low-level laser therapy versus clonazepam in patients with burning mouth syndrome. Lasers in Medical Science. 2016; 31: 811–816.

[24] Lončar-Brzak B, Škrinjar I, Brailo V, Vidović-Juras D, Šumilin L, Andabak-Rogulj A. Burning mouth syndrome (BMS)-treatment with verbal and written information, B vitamins, probiotics, and low level laser therapy: a randomized clinical trial. Dentistry Journal. 2022; 10: 44.

[25] Romeo U, Del Vecchio A, Capocci M, Maggiore C, Ripari M. The low level laser therapy in the management of neurological burning mouth syndrome. A pilot study. Ann Stomatol. 2010; 1: 14–18.

[26] Brailo V, Bosnjak A, Boras VV, Jurisic AK, Pelivan I, Kraljevic-Simunkovic S. Laser acupuncture in the treatment of burning mouth syndrome: a pilot study. Acupuncture in Medicine. 2013; 31: 453–454.

[27] Santos LDFCD, Carvalho ADAT, Leão JC, Cruz Perez DED, Castro JFLD. Effect of low-level laser therapy in the treatment of burning mouth syndrome: a case series. Photomedicine and Laser Surgery. 2011; 29: 793–796.

[28] dos Santos LDFC, de Andrade SC, Nogueira GEC, Leão JC, de Freitas PM. Phototherapy on the treatment of burning mouth syndrome: a prospective analysis of 20 cases. Photochemistry and Photobiology. 2015; 91: 1231–1236.

[29] Balcheva M, Balcheva G, Panov V, Madjova C. Low-level laser therapy in cases of burning mouth syndrome. Journal of Physics: Conference Series. 2021; 1859: 012036.

[30] Barbosa NG, Gonzaga AKG, de Sena Fernandes LL, da Fonseca AG, Queiroz SIML, Lemos TMAM, et al. Evaluation of laser therapy and alpha-lipoic acid for the treatment of burning mouth syndrome: a randomized clinical trial. Lasers in Medical Science. 2018; 33: 1255–1262.

[31] Arbabi-Kalati F, Bakhshani N, Rasti M. Evaluation of the efficacy of low-level laser in improving the symptoms of burning mouth syndrome. Journal of Clinical and Experimental Dentistry. 2015; 7: e524–e527.

[32] Valenzuela S, Lopez‐Jornet P. Effects of low‐level laser therapy on burning mouth syndrome. Journal of Oral Rehabilitation. 2017; 44: 125–132.

[33] Scardina GA, Casella S, Bilello G, Messina P. Photobiomodulation therapy in the management of burning mouth syndrome: morphological variations in the capillary bed. Dentistry Journal. 2020; 8: 99.

[34] Spanemberg J, Segura-Egea J, Rodriguez-de Rivera-Campillo E, Jane-Salas E, Salum F, Lopez-Lopez J. Low-level laser therapy in patients with burning mouth syndrome: a double-blind, randomized, controlled clinical trial. Journal of Clinical and Experimental Dentistry. 2019; 11: e162–e169.

[35] Sikora M, Včev A, Siber S, Vučićević Boras V, Rotim Ž, Matijević M. The efficacy of low-level laser therapy in burning mouth syndrome—a pilot study. Acta Clinica Croatica. 2018; 57: 312–315.

[36] Sugaya NN, Silva ÉF, Kato IT, Prates R, Gallo CDB, Pellegrini VD. Low intensity laser therapy in patients with burning mouth syndrome: a randomized, placebo-controlled study. Brazilian Oral Research. 2016; 30: e108.

[37] Škrinjar I, Lončar Brzak B, Vidranski V, Vučićević Boras V, Andabak Rogulj A, Pavelić B. Salivary cortisol levels and burning symptoms in patients with burning mouth syndrome before and after low level laser therapy: a double blind controlled randomized clinical trial. Acta Stomatologica Croatica. 2020; 54: 44–50.

[38] de Pedro M, López‐Pintor RM, Casañas E, Hernández G. Effects of photobiomodulation with low‐level laser therapy in burning mouth syndrome: a randomized clinical trial. Oral Diseases. 2020; 26: 1764–1776.

[39] Spanemberg JC, López JL, de Figueiredo MAZ, Cherubini K, Salum FG. Efficacy of low-level laser therapy for the treatment of burning mouth syndrome: a randomized, controlled trial. Journal of Biomedical Optics. 2015; 20: 098001.

[40] Sun C, Xu P, Zhang Q, Jiang W. Nd:YAG photobiomodulation treatment in burning mouth syndrome: a pilot study. Lasers in Dental Science. 2021; 5: 53–60.

[41] Grushka M, Epstein JB, Gorsky M. Burning mouth syndrome. American Family Physician. 2002; 65: 615–620.

[42] Antoun Reyad A, Mishriky R, Girgis E. Pharmacological and non-pharmacological management of burning mouth syndrome: a systematic review. Dental and Medical Problems. 2020; 57: 295–304.

[43] Savage NW, Boras VV, Barker K. Burning mouth syndrome: clinical presentation, diagnosis and treatment. Australasian Journal of Dermatology. 2006; 47: 77–83.

[44] Poli R, Parker S, Anagnostaki E, Mylona V, Lynch E, Grootveld M. Laser analgesia associated with restorative dental care: a systematic review of the rationale, techniques, and energy dose considerations. Dentistry Journal. 2020; 8: 128.

[45] Ślebioda Z, Dorocka-Bobkowska B. Low-level laser therapy in the treatment of recurrent aphthous stomatitis and oral lichen planus: a literature review. Advances in Dermatology and Allergology. 2020; 37: 475–481.

[46] Maia MLDM, Bonjardim LR, Quintans JDSS, Ribeiro MAG, Maia LGM, Conti PCR. Effect of low-level laser therapy on pain levels in patients with temporomandibular disorders: a systematic review. Journal of Applied Oral Science. 2012; 20: 594–602.

[47] Anschau F, Webster J, Capra MEZ, de Azeredo da Silva ALF, Stein AT. Efficacy of low-level laser for treatment of cancer oral mucositis: a systematic review and meta-analysis. Lasers in Medical Science. 2019; 34: 1053–1062.

[48] Carroll JD, Milward MR, Cooper PR, Hadis M, Palin WM. Developments in low level light therapy (LLLT) for dentistry. Dental Materials. 2014; 30: 465–475.

[49] Fornaini C, Fekrazad R, Rocca J, Zhang S, Merigo E. Use of blue and blue-violet lasers in dentistry: a narrative review. Journal of Lasers in Medical Sciences. 2021; 12: e31.

[50] Anders JJ, Lanzafame RJ, Arany PR. Low-level light/laser therapy versus photobiomodulation therapy. Photomedicine and Laser Surgery. 2015; 33: 183–184.

[51] Patton LL, Siegel MA, Benoliel R, De Laat A. Management of burning mouth syndrome: systematic review and management recommendations. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 2007; 103: S39.e1–S39.e13.

[52] Millum J, Grady C. The ethics of placebo-controlled trials: methodological justifications. Contemporary Clinical Trials. 2013; 36: 510–514.

[53] Hopewell S, Boutron I, Altman DG, Ravaud P. Incorporation of assessments of risk of bias of primary studies in systematic reviews of randomised trials: a cross-sectional study. BMJ Open. 2013; 3: e003342.

[54] Jørgensen L, Paludan-Müller AS, Laursen DRT, Savović J, Boutron I, Sterne JAC, et al. Evaluation of the Cochrane tool for assessing risk of bias in randomized clinical trials: overview of published comments and analysis of user practice in Cochrane and non-Cochrane reviews. Systematic Reviews. 2016; 5: 80.

[55] Slade GD, Spencer AJ. Development and evaluation of the oral health impact profile. Community Dental Health. 1994; 11: 3–11.

[56] Campos LA, Peltomäki T, Marôco J, Campos JADB. Use of oral health impact profile-14 (OHIP-14) in different contexts. What is being measured? International Journal of Environmental Research and Public Health. 2021; 18: 13412.

[57] Mascha EJ, Vetter TR. Significance, errors, power, and sample size: the blocking and tackling of statistics. Anesthesia & Analgesia. 2018; 126: 691–698.


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