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Abnormal functional hubs in migraine patients: a resting-state MRI analysis about voxel-wise degree centrality

  • Yi-Chao Chen1
  • Zi-Min Cao1
  • Guo-Yun Liu1
  • Zhi-Jun Li1
  • An-Qi Shi1
  • Jing-Nan Jia1
  • Jian-Wei Huo2,*,
  • Jun Wang1,*,
  • Chao-Qun Yan1,*,

1Department of Acupuncture and Moxibustion, Dongzhimen Hospital Beijing University of Chinese Medicine, 100700 Beijing, China

2Department of Radiology, Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University, 100010 Beijing, China

DOI: 10.22514/jofph.2024.006 Vol.38,Issue 1,March 2024 pp.52-63

Submitted: 22 February 2023 Accepted: 06 November 2023

Published: 12 March 2024

*Corresponding Author(s): Jian-Wei Huo E-mail: huojianwei@bjzhongyi.com
*Corresponding Author(s): Jun Wang E-mail: wangjunee@bucm.edu.cn
*Corresponding Author(s): Chao-Qun Yan E-mail: yanchaoqun857@bucm.edu.cn

Abstract

The purpose was to explore the spatial centrality of the whole brain functional network related to migraine and to investigate the potential functional hubs associated with migraine. 32 migraine patients and 55 healthy controls were recruited and they received resting-state functional magnetic resonance imaging voluntarily. Voxel-wise Degree Centrality (DC) was measured across the whole brain, and group differences in DC were compared. False Discovery Rate and permutation test (5000 times) were used for multiple comparisons. Finally, significant differences in functional connectivity (FC) between seeds and other brain regions were further researched by the seed-based approach. The correlation analyses between the changes in the brain function and clinical features were also performed. The results showed that, compared to healthy controls, migraine patients exhibited significantly increased DC in the left anterior cingulate cortex (ACC), slightly increased DC in the right ACC and the right medial superior frontal gyrus (SFG). No significant correlation was found between DC and clinical variables. The seed-based analyses showed that migraine patients showed increased FC between the right SFG and left ACC, decreased FC between the left ACC and left superior temporal gyrus (STG). FC value of the right SFG was positively correlated with the score of migraine-specific quality-of-life questionnaire about role in function-preventive in migraine patients. According to relatively changed DC, we found that migraine patients exhibited specific abnormal intrinsic functional hubs. These findings expand our understanding of functional characteristics of migraine, and may provide new insights into understanding the dysfunction and pathophysiology of migraine patients.


Keywords

Migraine; Pain; Degree centrality; Functional connectivity; Resting-state fMRI


Cite and Share

Yi-Chao Chen,Zi-Min Cao,Guo-Yun Liu,Zhi-Jun Li,An-Qi Shi,Jing-Nan Jia,Jian-Wei Huo,Jun Wang,Chao-Qun Yan. Abnormal functional hubs in migraine patients: a resting-state MRI analysis about voxel-wise degree centrality. Journal of Oral & Facial Pain and Headache. 2024. 38(1);52-63.

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