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Systematic reviews

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Prevalence of orofacial and head pain: an umbrella review of systematic reviews

  • André Luís Porporatti1,*,†,
  • Ângela Graciela Deliga Schroder2,†
  • Ashley Lebel1,3
  • Nathan Moreau1,4
  • Charlotte Guillouet1,5
  • José Stechman-Neto2
  • Yves Boucher1,3

1Laboratory of Orofacial NeuroBiology (EA 7543), Faculty of Dentistry, Paris-Cité University, 92120 Paris, France

2NARSM (Systematic Review and Meta-analysis Center), Tuiuti University of Paraná-UTP, 82.010-210 Curitiba, PR, Brazil

3Pitié Salpêtrière Hospital (AP-HP), 75013 Paris, France

4Bretonneau Hospital (AP-HP), 75018 Paris, France

5Rothschild Hospital (AP-HP), 75012 Paris, France

DOI: 10.22514/jofph.2024.022 Vol.38,Issue 3,September 2024 pp.1-14

Submitted: 07 February 2024 Accepted: 25 April 2024

Published: 12 September 2024

*Corresponding Author(s): André Luís Porporatti E-mail: andre.porporatti@u-paris.fr

† These authors contributed equally.

Abstract

Head pain (HP) and orofacial pain (OFP) are the most prevalent types of pain worldwide, encompassing cranial, oral and facial pain. The aim of this umbrella review was to answer the following questions: “What is the overall prevalence of HP/OFP and the different prevalences of HP/OFP conditions in adults and children?”. We searched for studies investigating the prevalence of HP/OFP in four major databases and two databases from the grey literature, based on the following PECOS inclusion criteria:(P)opulation: Adults and children; (E)xposure: Orofacial or head pain conditions such as (1) dental, periodontal and gingival, (2) temporomandibular disorders (TMD), (3) neuropathic conditions, (4) headaches, and (5) idiopathic pain conditions; (C)omparison: None; (O)utcome: Prevalence; (S)tudies: Systematic reviews and/or meta-analyses. We identified 2275 studies and after selection through eligibility criteria, 24 systematic reviews were included. The prevalence of pain in adults for different subgroups ranged from 1.12% for Burning Mouth Syndrome to 80.80% for cancer therapy-related orofacial pain. In children, it ranged from 0.20% for temporomandibular joint osteoarthrosis to 83% for all types of headache. This umbrella review based on available evidence provides integrated data illustrating the highly variable prevalence of head pain and orofacial pain both in adults and children. Considering the high specificity of head pain/orofacial pain, specific public health programs should be developed to address such highly prevalent conditions.


Keywords

Prevalence; Orofacial pain; Headache; Temporomandibular disorder; Neuropathic pain; Umbrella review


Cite and Share

André Luís Porporatti,Ângela Graciela Deliga Schroder,Ashley Lebel,Nathan Moreau,Charlotte Guillouet,José Stechman-Neto,Yves Boucher. Prevalence of orofacial and head pain: an umbrella review of systematic reviews. Journal of Oral & Facial Pain and Headache. 2024. 38(3);1-14.

References

[1] Ziegeler C, May A. The ICHD definition of ‘facial pain’ should be revised. Cephalalgia. 2020; 40: 1398–1399.

[2] International classification of orofacial pain, 1st edition (ICOP). Cephalalgia. 2020; 40: 129–221.

[3] Handa S, Keith DA, Abou-Ezzi J, Rosèn A. Neuropathic orofacial pain: characterization of different patient groups using the ICOP first edition, in a tertiary level orofacial pain clinic. Oral surgery, Oral Medicine, Oral Pathology and Oral Radiology. 2021; 132: 653–661.

[4] De Laat AP. Pain in Europe. IV. Fourth congress of the European federation of IASP chapters (EFIC). Journal of Orofacial Pain. 2004; 18: 69–70.

[5] Nicholas M, Vlaeyen JWS, Rief W, Barke A, Aziz Q, Benoliel R, et al. The IASP classification of chronic pain for ICD-11: chronic primary pain. Pain. 2019; 160: 28–37.

[6] Raja SN, Carr DB, Cohen M, Finnerup NB, Flor H, Gibson S, et al. The revised international association for the study of pain definition of pain: concepts, challenges, and compromises. Pain. 2020; 161: 1976–1982.

[7] Pigg M, Nixdorf DR, Law AS, Renton T, Sharav Y, Baad-Hansen L, et al. New international classification of orofacial pain: what is in it for endodontists? Journal of Endodontics. 2021; 47: 345–357.

[8] Badel T, Zadravec D, Bašić Kes V, Smoljan M, Kocijan Lovko S, Zavoreo I, et al. Orofacial pain—diagnostic and therapeutic challenges. Acta Clinica Croatica. 2019; 58: 82–89.

[9] Goadsby PJ, Evers S. International classification of headache disorders—ICHD-4 alpha. Cephalalgia. 2020; 40: 887–888.

[10] Schiffman E, Ohrbach R, Truelove E, Look J, Anderson G, Goulet JP, et al. Diagnostic criteria for temporomandibular disorders (DC/TMD) for clinical and research applications: recommendations of the international RDC/TMD Consortium Network and Orofacial Pain Special Interest Group. Journal of Oral & Facial Pain and Headache. 2014; 28: 6–27.

[11] Perrot S, Cohen M, Barke A, Korwisi B, Rief W, Treede R. The IASP classification of chronic pain for ICD-11: chronic secondary musculoskeletal pain. Pain. 2019; 160: 77–82.

[12] Benoliel R, Svensson P, Evers S, Wang S, Barke A, Korwisi B, et al. The IASP classification of chronic pain for ICD-11: chronic secondary headache or orofacial pain. Pain. 2019; 160: 60–68.

[13] Okeson JP. The classification of orofacial pains. Oral and Maxillofacial Surgery Clinics of North America. 2008; 20: 133–144.

[14] Dworkin SF, LeResche L. Research diagnostic criteria for temporomandibular disorders: review, criteria, examinations and specifications, critique. Journal of Craniomandibular Disorders. 1992; 6: 301–355.

[15] Okeson JP. Bell’s oral and facial pain. 7th edn. Quintessence: Chicago, IL. 2014.

[16] Macfarlane TV, Blinkhorn AS, Davies RM, Kincey J, Worthington HV. Oro-facial pain in the community: prevalence and associated impact. Community Dentistry and Oral Epidemiology. 2002; 30: 52–60.

[17] Crandall JA. An introduction to orofacial pain. Dental Clinics of North America. 2018; 62: 511–523.

[18] Heir GM. Introduction to orofacial pain. Alpha Omegan. 2012; 105: 58–60.

[19] Moher D, Liberati A, Tetzlaff J, Altman DG; PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLOS Medicine. 2009; 6: e1000097.

[20] Needleman IG. A guide to systematic reviews. Journal of Clinical Periodontology. 2002; 29: 6–9.

[21] Higgins J, Green S. Cochrane handbook for systematic reviews of interventions Version 5.1.0. 2011. Available at: http://handbook.cochrane.org/ (Accessed: 15 October 2023).

[22] De Toledo IP, Conti Réus J, Fernandes M, Porporatti AL, Peres MA, Takaschima A, et al. Prevalence of trigeminal neuralgia. The Journal of the American Dental Association. 2016; 147: 570–576.e2.

[23] Macfarlane TV, Wirth T, Ranasinghe S, Ah-See KW, Renny N, Hurman D. Head and neck cancer pain: systematic review of prevalence and associated factors. Journal of Oral & Maxillofacial Research. 2012; 3: e1.

[24] Macfarlane TV, Glenny A, Worthington HV. Systematic review of population-based epidemiological studies of oro-facial pain. Journal of Dentistry. 2001; 29: 451–467.

[25] Wu S, Zhang W, Yan J, Noma N, Young A, Yan Z. Worldwide prevalence estimates of burning mouth syndrome: a systematic review and meta-analysis. Oral Diseases. 2022; 28: 1431–1440.

[26] Epstein JB, Hong C, Logan RM, Barasch A, Gordon SM, Oberlee-Edwards L, et al. A systematic review of orofacial pain in patients receiving cancer therapy. Supportive Care in Cancer. 2010; 18: 1023–1031.

[27] Liao ZW, Le C, Kynes JM, Niconchuk JA, Pinto E, Laferriere HE, et al. Paediatric chronic pain prevalence in low- and middle-income countries: a systematic review and meta-analysis. eClinicalMedicine. 2022; 45: 101296.

[28] King S, Chambers CT, Huguet A, MacNevin RC, McGrath PJ, Parker L, et al. The epidemiology of chronic pain in children and adolescents revisited: a systematic review. Pain. 2011; 152: 2729–2738.

[29] Favaro Zeola L, Soares PV, Cunha-Cruz J. Prevalence of dentin hypersensitivity: systematic review and meta-analysis. Journal of Dentistry. 2019; 81: 1–6.

[30] Santos PS, Barasuol JC, Moccelini BS, Magno MB, Bolan M, Martins-Junior PA, et al. Prevalence of toothache and associated factors in children and adolescents: a systematic review and meta-analysis. Clinical Oral Investigations. 2022; 26: 1105–1119.

[31] Al-Khazali HM, Al-Khazali S, Iljazi A, Christensen RH, Ashina S, Lipton RB, et al. Prevalence and clinical features of hemicrania continua in clinic-based studies: a systematic review and meta-analysis. Cephalalgia. 2023; 43: 3331024221131343.

[32] Albalawi MF, Alanazi WL, Albalawi HS, Alghannami SS, Albalawi AF. Prevalence of migraine headache in Saudi Arabia: a systematic review and meta-analysis. Cureus. 2023; 15: e37560.

[33] Dhiman V, Menon GR, Kaur S, Mishra A, John D, Rao Vishnu MV, et al. A systematic review and meta-analysis of prevalence of epilepsy, dementia, headache, and parkinson disease in India. Neurology India. 2021; 69: 294–301.

[34] El-Metwally A, Toivola P, AlAhmary K, Bahkali S, AlKhathaami A, Al Ammar SA, et al. The epidemiology of migraine headache in Arab countries: a systematic review. the Scientific World Journal. 2020; 2020: 4790254.

[35] Farhadi Z, Alidoost S, Behzadifar M, Mohammadibakhsh R, Khodadadi N, Sepehrian R, et al. The prevalence of migraine in Iran: a systematic review and meta-analysis. Iranian Red Crescent Medical Journal. 2016; 18: e40061.

[36] Mohammadi P, Khodamorovati M, Vafaee K, Hemmati M, Darvishi N, Ghasemi H. Prevalence of migraine in Iran: a systematic review and meta-analysis. BMC Neurology. 2023; 23: 172.

[37] Abu-Arafeh I, Razak S, Sivaraman B, Graham C. Prevalence of headache and migraine in children and adolescents: a systematic review of population-based studies. Developmental Medicine & Child Neurology. 2010; 52: 1088–1097.

[38] Asraf NO, Algabri MO, Alotaibi TFO, Alhamad SA, Al Hamad MA, Almuqrin SM, et al. Prevalence and risk factors of migraine in children, a systematic review. International Journal of Life Science and Pharma Research. 2022; 13: L35–L42.

[39] Onofri A, Pensato U, Rosignoli C, Wells-Gatnik W, Stanyer E, Ornello R, et al. Primary headache epidemiology in children and adolescents: a systematic review and meta-analysis. The Journal of Headache and Pain. 2023; 24: 8.

[40] van Hecke O, Austin SK, Khan RA, Smith BH, Torrance N. Neuropathic pain in the general population: a systematic review of epidemiological studies. Pain. 2014; 155: 654–662.

[41] Melo V, Monteiro L, Orge C, Sales M, Melo J, Rodrigues B, et al. Prevalence of temporomandibular disorders in the Brazilian population: a systematic review and meta-analysis. To be published in Cranio. 2023. [Preprint].

[42] Pantoja LLQ, de Toledo IP, Pupo YM, Porporatti AL, De Luca Canto G, Zwir LF, et al. Prevalence of degenerative joint disease of the temporomandibular joint: a systematic review. Clinical Oral Investigations. 2019; 23: 2475–2488.

[43] Valesan LF, Da-Cas CD, Réus JC, Denardin ACS, Garanhani RR, Bonotto D, et al. Prevalence of temporomandibular joint disorders: a systematic review and meta-analysis. Clinical Oral Investigations. 2021; 25: 441–453.

[44] Christidis N, Lindström Ndanshau E, Sandberg A, Tsilingaridis G. Prevalence and treatment strategies regarding temporomandibular disorders in children and adolescents—a systematic review. Journal of Oral Rehabilitation. 2019; 46: 291–301.

[45] Minervini G, Franco R, Marrapodi MM, Fiorillo L, Cervino G, Cicciù M. Prevalence of temporomandibular disorders in children and adolescents evaluated with diagnostic criteria for temporomandibular disorders: a systematic review with meta-analysis. Journal of Oral Rehabilitation. 2023; 50: 522–530.

[46] Breivik H, Collett B, Ventafridda V, Cohen R, Gallacher D. Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment. European Journal of Pain. 2006; 10: 287–333.

[47] Edwards D, Rasaiah S, Hamzah Ahmed S, Breckons M, Stone SJ, Currie CC, et al. The financial and quality of life impact of urgent dental presentations: a cross-sectional study. International Endodontic Journal. 2023; 56: 697–709.

[48] Harris L, L’Italien G, Kumar A, Seelam P, LaVallee C, Coric V, et al. Real-world assessment of the relationship between migraine-related disability and healthcare costs in the United States. Headache. 2022; 62: 473–481.

[49] Gil-Gouveia R, Miranda R. Indirect costs attributed to headache: a nation-wide survey of an active working population. Cephalalgia. 2022; 42: 317–325.

[50] Van der Cruyssen F, Nys M, Renton T, Vandeleene G, Callens M, Vanhaecht K, et al. Healthcare costs of post-traumatic trigeminal neuropathy in Belgium—a retrospective analysis. Journal of Cranio-Maxillofacial Surgery. 2022; 50: 627–636.

[51] Durham J, Breckons M, Vale L, Shen J. DEEP study: modeling outcomes and costs of persistent orofacial pain. JDR Clinical & Translational Research. 2023; 8: 16–26.

[52] Todd A, McNamara CL, Balaj M, Huijts T, Akhter N, Thomson K, et al. The European epidemic: pain prevalence and socioeconomic inequalities in pain across 19 European countries. European Journal of Pain. 2019; 23: 1425–1436.

[53] Park S, Han S, Suh HS. The disease burden of migraine patients receiving prophylactic treatments in Korea: a population-based claims database analysis. BMC Health Services Research. 2022; 22: 902.

[54] Lautenbacher S, Peters JH, Heesen M, Scheel J, Kunz M. Age changes in pain perception: a systematic-review and meta-analysis of age effects on pain and tolerance thresholds. Neuroscience and Biobehavioral Reviews. 2017; 75: 104–113.

[55] Craig KD. A child in pain: a psychologist’s perspective on changing priorities in scientific understanding and clinical care. Paediatric and Neonatal Pain. 2020; 2: 40–49.

[56] Stovner LJ, Hagen K, Linde M, Steiner TJ. The global prevalence of headache: an update, with analysis of the influences of methodological factors on prevalence estimates. The Journal of Headache and Pain. 2022; 23: 34.

[57] Rikard SM, Strahan AE, Schmit KM, Guy GP. Chronic pain among adults—United States, 2019–2021. Morbidity and Mortality Weekly Report. 2023; 72: 379–385.

[58] World Health Organization. World health statistics 2023: monitoring health for the SDGs, sustainable development goals. World Health Organization: Geneva. 2023.

[59] Hargreaves KM. Orofacial pain. Pain. 2011; 152: S25–S32.

[60] Panneton WM, Gan Q, Livergood RS. A trigeminoreticular pathway: implications in pain. PLOS ONE. 2011; 6: e24499.

[61] May A, Svensson P. One nerve, three divisions, two professions and nearly no crosstalk? Cephalalgia. 2017; 37: 603–603.

[62] von Arx T, Abdelkarim AZ, Lozanoff S. The face—a neurosensory perspective. Swiss Dental Journal. 2017; 127: 1066–1075.

[63] Terrier L, Hadjikhani N, Destrieux C. The trigeminal pathways. Journal of Neurology. 2022; 269: 3443–3460.

[64] Ziegeler C, May A. Facial presentations of migraine, TACs, and other paroxysmal facial pain syndromes. Neurology. 2019; 93: e1138–e1147.

[65] Peng KP, Benoliel R, May A. A review of current perspectives on facial presentations of primary headaches. Journal of Pain Research. 2022; 15: 1613–1621.

[66] Lopez-Lopez J, Garcia-Vicente L, Jane-Salas E, Estrugo-Devesa A, Chimenos-Kustner E, Roca-Elias J. Orofacial pain of cardiac origin: Review literature and clinical cases. Medicina Oral Patología Oral y Cirugia Bucal. 2012; 17: e538–e544.

[67] Marfurt CF, Rajchert DM. Trigeminal primary afferent projections to “non-trigeminal” areas of the rat central nervous system. Journal of Comparative Neurology. 1991; 303: 489–511.

[68] Pfaller K, Arvidsson J. Central distribution of trigeminal and upper cervical primary afferents in the rat studied by anterograde transport of horseradish peroxidase conjugated to wheat germ agglutinin. Journal of Comparative Neurology. 1988; 268: 91–108.

[69] Lv X, Wu Z, Li Y. Innervation of the cerebral dura mater. The Neuroradiology Journal. 2014; 27: 293–298.

[70] Luz LL, Fernandes EC, Dora F, Lukoyanov NV, Szucs P, Safronov BV. Trigeminal Aδ- and C-afferent supply of lamina I neurons in the trigeminocervical complex. Pain. 2019; 160: 2612–2623.

[71] Basedau H, Nielsen T, Asmussen K, Gloss K, Mehnert J, Jensen RH, et al. Experimental evidence of a functional relationship within the brainstem trigeminocervical complex in humans. Pain. 2022; 163: 729–734.

[72] Mehnert J, Basedau H, Sturm L, Nielsen T, Jensen RH, May A. Functional brainstem representations of the human trigeminal cervical complex. Cephalalgia. 2023; 43: 033310242311748.

[73] Piovesan EJ, Kowacs PA, Oshinsky ML. Convergence of cervical and trigeminal sensory afferents. Current Pain and Headache Reports. 2003; 7: 377–383.

[74] Terrier LM, Fontaine D. Intracranial nociception. Revue Neurologique. 2021; 177: 765–772.

[75] Mørch CD, Hu JW, Arendt‐Nielsen L, Sessle BJ. Convergence of cutaneous, musculoskeletal, dural and visceral afferents onto nociceptive neurons in the first cervical dorsal horn. European Journal of Neuroscience. 2007; 26: 142–154.

[76] Shigenaga Y, Sera M, Nishimori T, Suemune S, Nishimura M, Yoshida A, et al. The central projection of masticatory afferent fibers to the trigeminal sensory nuclear complex and upper cervical spinal cord. Journal of Comparative Neurology. 1988; 268: 489–507.

[77] Lucchi ML, Scapolo PA, Barazzoni AM, Clavenzani P, Costerbosa GL, Berardinelli P, et al. Mesencephalic trigeminal nucleus neurons supplying the jaw closing muscles have no spinal projection: a fluorescent double-labeling study in birds and mammals. The Anatomical Record. 1997; 249: 255–258.

[78] de Wijer A, Steenks MH, de Leeuw JR, Bosman F, Helders PJ. Symptoms of the cervical spine in temporomandibular and cervical spine disorders. Journal of Oral Rehabilitation. 1996; 23: 742–750.

[79] Türp JC, Kowalski CJ, O’Leary N, Stohler CS. Pain maps from facial pain patients indicate a broad pain geography. Journal of Dental Research. 1998; 77: 1465–1472.

[80] Shea BJ, Reeves BC, Wells G, Thuku M, Hamel C, Moran J, et al. AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both. The BMJ. 2017; 358: j4008.

[81] Paez A. Grey literature: An important resource in systematic reviews. To be published in Journal of Evidence-Based Medicine. 2017. [Preprint].

[82] Melo G, Duarte J, Pauletto P, Porporatti AL, Stuginski‐Barbosa J, Winocur E, et al. Bruxism: an umbrella review of systematic reviews. Journal of Oral Rehabilitation. 2019; 46: 666–690.

[83] Salarić I, Sabalić M, Alajbeg I. Opiorphin in burning mouth syndrome patients: a case-control study. Clinical Oral Investigations. 2017; 21: 2363–2370.

[84] Nater UM, Rohleder N. Salivary alpha-amylase as a non-invasive biomarker for the sympathetic nervous system: current state of research. Psychoneuroendocrinology. 2009; 34: 486–496.

[85] Krahel A, Paszynska E, Otulakowska-Skrzynska J, Rzatowski S, Hernik A, Slopien A, et al. Salivary Biomarkers (Opiorphin, Cortisol, Amylase, and IgA) related to age, sex, and stress perception in a prospective cohort of healthy schoolchildren. Mediators of Inflammation. 2021; 2021: 1–14.

[86] Lavigne GJ, Sessle BJ. The neurobiology of orofacial pain and sleep and their interactions. Journal of Dental Research. 2016; 95: 1109–1116.

[87] Asmundson GJ, Katz J. Understanding the co-occurrence of anxiety disorders and chronic pain: state-of-the-art. Depression and Anxiety. 2009; 26: 888–901.

[88] Turk DC, Dworkin RH, Revicki D, Harding G, Burke LB, Cella D, et al. Identifying important outcome domains for chronic pain clinical trials: an IMMPACT survey of people with pain. Pain. 2008; 137: 276–285.

[89] Farag AM, Albuquerque R, Ariyawardana A, Chmieliauskaite M, Forssell H, Nasri-Heir C, et al. World workshop in oral medicine VII: reporting of IMMPACT-recommended outcome domains in randomized controlled trials of burning mouth syndrome: a systematic review. Oral Diseases. 2019; 25: 122–140.


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