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Systematic reviews

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Prevalence of temporomandibular disorder in irritable bowel syndrome (IBS) patients: a systematic review

  • Michele Cricri1,*,
  • Gaetano Luglio2
  • Francesca Tropeano3
  • Antonio Miele1
  • Giovanni Domenico De Palma1
  • Maria Maddalena Marrapodi4,*,
  • Diana Russo5
  • Marco Cicciù6
  • Giuseppe Minervini5,7

1Endoscopic Surgery Unit, Department of Clinical Medicine and Surgery, University of Naples “Federico II”, 80131 Naples, Italy

2Endoscopic Surgery Unit, Department of Public Health, University of Naples “Federico II”, 80131 Naples, Italy

3Endoscopic Surgery Unit, Department of Advanced Biomedical Sciences, University of Naples “Federico II”, 80131 Naples, Italy

4Department of Woman, Child and General and Specialist Surgery, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy

5Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy

6Department of Biomedical and Surgical and Biomedical Sciences, Catania University, 95123 Catania, Italy

7Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, 600077 Chennai, India

DOI: 10.22514/jofph.2025.026 Vol.39,Issue 2,June 2025 pp.66-74

Submitted: 06 November 2024 Accepted: 31 December 2024

Published: 12 June 2025

*Corresponding Author(s): Michele Cricri E-mail: michele.cricri@unina.it
*Corresponding Author(s): Maria Maddalena Marrapodi E-mail: mariamaddalena.marrapodi@studenti.unicampania.it

Abstract

Background: Temporomandibular disorders (TMD) refer to a collection of pathological conditions that impact the stomatognathic system, often associated with psychiatric comorbidities. Interestingly, previous studies have reported a higher prevalence of TMD in individuals affected by irritable bowel syndrome (IBS), a condition commonly linked to stress-induced psychosomatic factors. The aim of this systematic review is to clarify the prevalence of TMD in IBS-diagnosed patients. Methods: A systematic search was conducted in PubMed, Scopus, Web of Science and Cochrane Library databases up to May 2024, following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and the Cochrane Handbook for Systematic Reviews of Interventions. Eligibility criteria included studies reporting prevalence data on TMD in IBS patients. Study quality was assessed using the Risk of Bias in Non-randomized Studies-of Exposure (ROBINS-E) tool. Results: A total of five studies, involving 3138 patients, were included. TMD prevalence was significantly higher in IBS patients compared to pooled controls. However, no significant differences were observed among IBS subtypes regarding TMD prevalence. Conclusions: This review highlights a substantially higher prevalence of TMD in IBS patients compared to the general population, suggesting a shared pathophysiological mechanism likely linked to stress response systems. These findings underscore the need for a multidisciplinary approach to patient management and emphasize the importance of further research to explore the causal links and underlying mechanisms between IBS and TMD. The PROSPERO Registration: The protocol has been registered on the International Prospective Register of Systematic Reviews (PROSPERO) with the number CRD42024542233.


Keywords

Temporomandibular disorders; Irritable bowel syndrome; Prevalence; Systematic review; Meta-analysis; Psychosomatic disorders


Cite and Share

Michele Cricri, Gaetano Luglio, Francesca Tropeano, Antonio Miele, Giovanni Domenico De Palma, Maria Maddalena Marrapodi, Diana Russo, Marco Cicciù, Giuseppe Minervini. Prevalence of temporomandibular disorder in irritable bowel syndrome (IBS) patients: a systematic review. Journal of Oral & Facial Pain and Headache. 2025. 39(2);66-74.

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