Title
Author
DOI
Article Type
Special Issue
Volume
Issue
Synovial chondromatosis of the temporomandibular joint: a case report with an associated systematic review update of the literature
1Department of Medical Biotechnologies, School of Dentistry, University of Siena, 53100 Siena, Italy
2Unit of Oral and Maxillofacial Surgery, Ca’Foncello Hospital, 31100 Treviso, Italy
DOI: 10.22514/jofph.2025.068 Vol.39,Issue 4,December 2025 pp.70-84
Submitted: 11 May 2025 Accepted: 10 July 2025
Published: 12 December 2025
*Corresponding Author(s): Ovidiu Ionut Saracutu E-mail: Ovidiu.saracutu@unisi.it
Background: This study aims to report a case of synovial chondromatosis (SC) of the left temporomandibular joint (TMJ) and provide an update of a previous review published in 2010 by summarizing the last 15 years of literature on the topic. Methods: On 07 July 2024, two of the authors independently performed a systematic search in the most relevant medical databases to identify all the English-language papers reporting cases of TMJ SC. After selecting the articles, the authors discussed their potential inclusion in the systematic review, and in case of disagreement, a third author was consulted. Results: From the assessment of all four databases, 466 citations were retrieved. After the removal of the duplicates, 136 articles remained for evaluation. In the end, a total of 108 articles were selected for inclusion, reporting a total of 1046 cases of SC of the TMJ. The most frequently reported signs and symptoms were pain, reduced interincisal mouth opening, swelling, crepitus, and clicking. Conclusions: Despite the different surgical treatment options that were adopted, the recurrence rate remains low. From the present review, no evidence arises for a specific risk factor for TMJ SC. The PROSPERO Registration: register number CRD42024568102.
Synovial chondromatosis; Temporomandibular joint surgery; Arthroscopy; Case report; Systematic review; Treatment; Magnetic resonance imaging; TMJ pathology; Differential diagnosis
Ovidiu Ionut Saracutu,Matteo Val,Luca Guarda-Nardini,Marco Ferrari,Matteo Pollis,Daniele Manfredini. Synovial chondromatosis of the temporomandibular joint: a case report with an associated systematic review update of the literature. Journal of Oral & Facial Pain and Headache. 2025. 39(4);70-84.
[1] Sbaraglia M, Bellan E, Dei Tos AP. The 2020 WHO classification of soft tissue tumours: news and perspectives. Pathologica. 2021; 113: 70–84.
[2] Barwell R. Clinical lectures on movable bodies in joints. British Medical Journal. 1876; 1: 403–405.
[3] Tripathy SR, Parida MK, Thatoi PK, Mishra A, Das BK. Primary synovial chondromatosis (Reichel Syndrome). The Lancet Rheumatology. 2020; 2: e576.
[4] Guarda-Nardini L, Piccotti F, Ferronato G, Manfredini D. Synovial chondromatosis of the temporomandibular joint: a case description with systematic literature review. International Journal of Oral and Maxillofacial Surgery. 2010; 39: 745–755.
[5] Bouloux GF, Greene CS, Mercuri LG. Intraarticular TMJ pain and dysfunction—2024-invited guest editorial. CRANIO®. 2024; 42: 481–482.
[6] Greene CS. “The emperor’s new clothes”—reflection on the ethics of second opinions in the TMD field. CRANIO®. 2025; 43: 173–174.
[7] Manfredini D, Chiappe G, Bosco M. Research diagnostic criteria for temporomandibular disorders (RDC/TMD) axis I diagnoses in an Italian patient population. Journal of Oral Rehabilitation. 2006; 33: 551–558.
[8] Wu S, Xia S, Yue S, Bai G, Chen M, Yang C. Clinical guidance based on MRI for the management of temporomandibular joint synovial chondromatosis: one institution’s experience. Journal of Cranio-Maxillofacial Surgery. 2024; 52: 1434–1440.
[9] Smith SC, Snyder GM. Orthopedic management of a patient with synovial chondromatosis. JAAPA. 2025; 38: 34–37.
[10] Yu Q, Yang J, Wang P, Shi H, Luo J. CT features of synovial chondromatosis in the temporomandibular joint. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 2004; 97: 524–528.
[11] Flaman AN, Wasserman JK, Gravel DH, Purgina BM. Soft tissue special issue: chondroid neoplasms of the skull. Head and Neck Pathology. 2020;14: 83–96.
[12] Milgram JW. The classification of loose bodies in human joints. Clinical Orthopaedics and Related Research. 1977; 124: 282–291.
[13] Blankestijn J, Panders AK, Vermey A, Scherpbier AJ. Synovial chondromatosis of the temporo-mandibular joint. Report of three cases and a review of the literature. Cancer. 1985; 55: 479–485.
[14] Axhausen G. Pathology and treatment of the temporomandibular joint. Fortschr Zahnheilkunde. 1933; 9: 171–185. (In German)
[15] von Lindern JJ, Theuerkauf I, Niederhagen B, Bergé S, Appel T, Reich RH. Synovial chondromatosis of the temporomandibular joint: clinical, diagnostic, and histomorphologic findings. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 2002; 94: 31–38.
[16] Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. The BMJ. 2021; 372: n71.
[17] Moola S, Munn Z, Tufanaru C, Aromataris E, Sears K, Sfetcu R, et al. Systematic reviews of etiology and risk. In Aromataris E, Munn Z (eds.) JBI manual for evidence synthesis (pp. 101). 1st edn. JBI: Australia. 2020.
[18] Murakami KI, Yamamura I. Synovial chondromatosis of the lower compartment of the temporomandibular joint. Asian Journal of Oral and Maxillofacial Surgery. 2009; 21: 48–50.
[19] Balasundaram A, Geist JR, Gordon SC, Klasser GD. Radiographic diagnosis of synovial chondromatosis of the temporomandibular joint: a case report. Journal of the Canadian Dental Association. 2009; 75: 711–714.
[20] Sato J, Notani KI, Goto J, Shindoh M, Kitagawa Y. Synovial chondromatosis of the temporomandibular joint accompanied by loose bodies in both the superior and inferior joint compartments: case report. International Journal of Oral and Maxillofacial Surgery. 2010; 39: 86–88.
[21] Goizueta-Adame CC, González-García R. Synovial chondromatosis of the temporomandibular joint: report of 2 patients whose joints were reconstructed with costochondral graft and alloplastic prosthesis. British Journal of Oral and Maxillofacial Surgery. 2010; 48: 374–377.
[22] Chen MJ, Yang C, Zhang XH, Qiu YT. Synovial chondromatosis originally arising in the lower compartment of temporomandibular joint: a case report and literature review. Journal of Cranio-Maxillofacial Surgery. 2011; 39: 459–462.
[23] Meng J, Guo C, Yi B, Zhao Y, Luo H, Ma X. Clinical and radiologic findings of synovial chondromatosis affecting the temporomandibular joint. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 2010; 109: 441–448.
[24] Boffano P, Viterbo S, Bosco GF. Diagnosis and surgical management of synovial chondromatosis of the temporomandibular joint. Journal of Craniofacial Surgery. 2010; 21: 157–159.
[25] Pimenta e Souza D, Loureiro CC, Falchet PF, Leandro LF, Raitz R. Synovial chondromatosis of the temporomandibular joint: an asymptomatic case report and literature review. CRANIO®. 2010; 28: 67–71.
[26] Cai XY, Yang C, Chen MJ, Jiang B, Wang BL. Arthroscopically guided removal of large solitary synovial chondromatosis from the temporomandibular joint. International Journal of Oral and Maxillofacial Surgery. 2010; 39: 1236–1239.
[27] Testaverde L, Perrone A, Caporali L, Ermini A, Izzo L, D’Angeli I, et al. CT and MR findings in synovial chondromatosis of the temporo-mandibular joint: our experience and review of literature. European Journal of Radiology. 2011; 78: 414–418.
[28] González-Pérez LM, Congregado-Córdoba J, Salinas-Martín MV. Temporomandibular joint synovial chondromatosis with a traumatic etiology. International Journal of Oral and Maxillofacial Surgery. 2011; 40: 330–334.
[29] Guijarro-Martínez R, Puche Torres M, Marqués Mateo M, Solís García I, Miragall Alba L, Iglesias Gimilio ME, et al. Bilateral synovial chondromatosis of the temporomandibular joint. Journal of Cranio-Maxillofacial Surgery. 2011; 39: 261–265.
[30] Varol A, Sencimen M, Gulses A, Altug HA, Dumlu A, Kurt B. Diagnostic importance of MRI and CT scans for synovial osteochondromatosis of the temporomandibular joint. CRANIO®. 2011; 29: 313–317.
[31] Campbell DI, De Silva RK, De Silva H, Sinon SH, Rich AM. Temporomandibular joint synovial chondromatosis with intracranial extension: a review and observations of patient observed for 4 years. Journal of Oral and Maxillofacial Surgery. 2011; 69: 2247–2252.
[32] Shah SB, Ramanojam S, Gadre PK, Gadre KS. Synovial chondromatosis of temporomandibular joint: journey through 25 decades and a case report. Journal of Oral and Maxillofacial Surgery. 2011; 69: 2795–2814.
[33] Fuller E, Bharatha A, Yeung R, Kassel EE, Aviv RI, Howard P, et al. Case of the month #166: synovial chondromatosis of the temporal mandibular joint. Canadian Association of Radiologists Journal. 2011; 62: 151–153.
[34] Mori Y, Kakudo K, Gotoh M, Kubo H, Akiyama H, Yotsui Y, et al. A case of synovial chondromatosis of the temporomandibular joint followed for 17 years. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 2011; 112: e35–e39.
[35] Lim SW, Jeon SJ, Choi SS, Choi KH. Synovial chondromatosis in the temporomandibular joint: a case with typical imaging features and pathological findings. British Journal of Radiology. 2011; 84: e213–e216.
[36] Phelan E, Griffin J, Timon C. Temporomandibular joint osteochondromatosis: an unusual cause of preauricular swelling. Annals of Otology, Rhinology & Laryngology. 2011; 120: 63–65.
[37] Cai XY, Yang C, Chen MJ, Jiang B, Zhou Q, Jin JM, et al. Arthroscopic management for synovial chondromatosis of the temporomandibular joint: a retrospective review of 33 cases. Journal of Oral and Maxillofacial Surgery. 2012; 70: 2106–2113.
[38] Matsumoto K, Sato T, Iwanari S, Kameoka S, Oki H, Komiyama K, et al. The use of arthrography in the diagnosis of temporomandibular joint synovial chondromatosis. Dentomaxillofacial Radiology. 2013; 42: 15388284.
[39] Jiang B, Yang C, Chen MJ, Cai XY. Synovial chondromatosis of the temporomandibular joint with articular eminence extension. Journal of Craniofacial Surgery. 2012; 23: 716–718.
[40] Chen MJ, Yang C, Cai XY, Jiang B, Qiu YT, Zhang XH. Synovial chondromatosis in the inferior compartment of the temporomandibular joint: different stages with different treatments. Journal of Oral and Maxillofacial Surgery. 2012; 70: e32–e38.
[41] Mikami T, Aomura T, Ohira A, Kumagai A, Hoshi H, Takeda Y. Three case reports of synovial chondromatosis of temporomandibular joint: histopathologic analyses of minute cartilaginous loose bodies from joint lavage fluid and comparison with phase II and III cases. Journal of Oral and Maxillofacial Surgery. 2012; 70: 2099–2105.
[42] Wang P, Tian Z, Yang J, Yu Q. Synovial chondromatosis of the temporomandibular joint: MRI findings with pathological comparison. Dentomaxillofacial Radiology. 2012; 41: 110–116.
[43] Wake M, Hamada Y, Kumagai K, Tanaka N, Ikeda Y, Nakatani Y, et al. Up-regulation of interleukin-6 and vascular endothelial growth factor—a in the synovial fluid of temporomandibular joints affected by synovial chondromatosis. British Journal of Oral and Maxillofacial Surgery. 2013; 51: 164–169.
[44] Kahraman AS, Kahraman B, Dogan M, Firat C, Samdanci E, Celik T. Synovial chondromatosis of the temporomandibular joint: radiologic and histopathologic findings. Journal of Craniofacial Surgery. 2012; 23: 1211–1213.
[45] Matsumura Y, Nomura J, Nakanishi K, Yanase S, Kato H, Tagawa T. Synovial chondromatosis of the temporomandibular joint with calcium pyrophosphate dihydrate crystal deposition disease (pseudogout). Dentomaxillofacial Radiology. 2012; 41: 703–707.
[46] van Dijk RR, Rutten MJ. Synovial chondromatosis of the temporomandibular joint. Journal of the Belgian Society of Radiology. 2012; 95: 164–165.
[47] Yoshida H, Tsuji K, Oshiro N, Wato M, Morita S. Preliminary report of Ki-67 reactivity in synovial chondromatosis of the temporomandibular joint: an immunohistochemical study. Journal of Cranio-Maxillofacial Surgery. 2013; 41: 473–475.
[48] Coleman H, Chandraratnam E, Morgan G, Gomes L, Bonar F. Synovial chondrosarcoma arising in synovial chondromatosis of the temporomandibular joint. Head and Neck Pathology. 2013; 7: 304–309.
[49] Zhu Y, Zheng C, Deng Y, Zhang Y, Hu X. Arthroscopic surgery for removal of 112 loose bodies of synovial chondromatosis of the temporomandibular joint. Journal of Craniofacial Surgery. 2013; 24: 2166–2169.
[50] Reed LS, Foster MD, Hudson JW. Synovial chondromatosis of the temporomandibular joint: a case report and literature review. CRANIO®. 2013; 31: 309–313.
[51] Pau M, Bicsák A, Reinbacher KE, Feichtinger M, Kärcher H. Surgical treatment of synovial chondromatosis of the temporomandibular joint with erosion of the skull base: a case report and review of the literature. International Journal of Oral and Maxillofacial Surgery. 2014; 43: 600–605.
[52] Peyrot H, Montoriol PF, Beziat JL, Barthelemy I. Synovial chondromatosis of the temporomandibular joint: CT and MRI findings. Diagnostic and Interventional Radiology. 2014; 95: 613–614.
[53] Sink J, Bell B, Mesa H. Synovial chondromatosis of the temporomandibular joint: clinical, cytologic, histologic, radiologic, therapeutic aspects, and differential diagnosis of an uncommon lesion. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 2014; 117: e269–e274.
[54] Li Y, Cai H, Fang W, Meng Q, Li J, Deng M, et al. Fibroblast growth factor 2 involved in the pathogenesis of synovial chondromatosis of temporomandibular joint. Journal of Oral Pathology & Medicine. 2014; 43: 388–394.
[55] Valentini V, Arangio P, Egidi S, Capriotti M, Vellone V, Castrechini M, et al. Diagnosis and treatment of synovial chondromatosis of the TMJ: a clinical case. Annali di Stomatologia. 2014; 4: 269–272.
[56] Cascone P, Gennaro P, Gabriele G, Chisci G, Mitro V, De Caris F, et al. Temporomandibular synovial chondromatosis with numerous nodules. Journal of Craniofacial Surgery. 2014; 25: 1114–1115.
[57] Droguett, C, Fumeaux, J, Skármeta NP. A case report of a primary synovial chondromatosis of temporomandibular joint, producing medial displacement of the articular disc. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 2014; 7: 92–96.
[58] Chen MJ, Yang C, Qiu YT, Jiang Q, Shi HM, Wei WB. Synovial chondromatosis of the tempromandibular joint: relationship between MRI information and potential aggressive behavior. Journal of Cranio-Maxillofacial Surgery. 2015; 43: 349–354.
[59] Pinto AA III, Ferreira e Costa R, de Sousa SF, Chagas MR, do Carmo MA, de Lacerda JC. Synovial Chondromatosis of the temporomandibular joint successfully treated by surgery. Head and Neck Pathology. 2015; 9: 525–529.
[60] Ochoa Escudero M, Juliano AF, Curtin HD. Inferior displacement of the lower belly of the lateral pterygoid muscle: a sign of temporomandibular joint lesions. Journal of Computer Assisted Tomography. 2015; 39: 340–342.
[61] Wang Y, Li L, Chen M, Yang C. Osteochondroma with secondary synovial chondromatosis in the temporomandibular joint. British Journal of Oral and Maxillofacial Surgery. 2016; 54: 454–456.
[62] Ivask O, Leibur E, Voog-Oras Ü. Synovial chondromatosis in the temporomandibular joint: case report with review of the literature. Stomatologija. 2015; 17: 97–101.
[63] Ionna F, Amantea M, Mastrangelo F, Ballini A, Maglione MG, Aversa C, et al. Innovative surgical management of the synovial chondromatosis of temporo-mandibular joints: highly conservative surgical technique. Journal of Craniofacial Surgery. 2016; 27: 1197–1201.
[64] Pastore GP, Goulart DR, Pastore PR, Prati AJ. Removal of a solitary synovial chondromatosis of the temporomandibular joint using arthroscopy. Journal of Craniofacial Surgery. 2016; 27: 967–969.
[65] Wake S, Yoshitake H, Kayamori K, Izumo T, Harada K. Expression of CD90 decreases with progression of synovial chondromatosis in the temporomandibular joint. CRANIO®. 2016; 34: 250–256.
[66] Yoshitake H, Kayamori K, Wake S, Sato F, Kino K, Harada K. Synovial chondromatosis of the right side temporomandibular joint extending to the middle cranial fossa: a case report with 7-year postoperative follow up and expression of a biomarker of cell proliferative activity. International Journal of Surgery Case Reports. 2016; 20: 133–137.
[67] Sozzi D, Bocchialini G, Novelli G, Valente MG, Moltrasio F, Bozzetti A. A rare case of synovial chondromatosis of the inferior TMJ compartment. Diagnosis and treatment aspect. Annali di Stomatologia. 2016; 6: 91–95.
[68] Paparo F, Massarelli M, Cordeschi R, Sciannameo V, Spallaccia F. Chondromatosis of the temporomandibular joint as a consequence of persistent long-lasting joint dysfunction: late diagnosis of a rare occurrence. Journal of Craniofacial Surgery. 2016; 27: e636–e637.
[69] Liu X, Huang Z, Zhu W, Liang P, Tao Q. Clinical and imaging findings of temporomandibular joint synovial chondromatosis: an analysis of 10 cases and literature review. Journal of Oral and Maxillofacial Surgery. 2016; 74: 2159–2168.
[70] Selvi F, Messina J, Faquin WC, Keith DA. Relapsing polychondritis concomitant with synovial chondromatosis of the temporomandibular joint. Journal of Oral and Maxillofacial Surgery. 2016; 74: 2207–2215.
[71] Leite PCC, Tolentino ES, Yamashita AL, Iwaki LCV, Iwaki Filho L. Surgical treatment of synovial chondromatosis in the inferior compartment of the temporomandibular joint with articular disc involvement. Journal of Craniofacial Surgery. 2018; 29: e199–e203.
[72] Pappot TW, Brouns JJ, Joosten J. Unusual extensive synovial chondromatosis of the temporomandibular joint. Journal of Craniofacial Surgery. 2017; 28: e172–e173.
[73] Bai G, Yang C, Qiu Y, Chen M. Open surgery assisted with arthroscopy to treat synovial chondromatosis of the temporomandibular joint. International Journal of Oral and Maxillofacial Surgery. 2017; 46: 208–213.
[74] Wilms CT, Heim N, Teschke M, Reich RR, Götz W. Synovial chondromatosis of the temporomandibular joint: immunohistochemical examinations regarding the role of insulin-like growth factors and their binding proteins in the etiology of this disease. Journal of Cranio-Maxillofacial Surgery. 2017; 45: 198–202.
[75] McCaffery C, Dodd M, Bekiroglu F, Twohig E. Synovial chondromatosis of the temporomandibular joint with extension into the middle cranial fossa and internal carotid canal. International Journal of Oral and Maxillofacial Surgery. 2017; 46: 867–870.
[76] Khanna JN, Ramaswami R. Synovial chondromatosis of the temporomandibular joint with intracranial extension-report of two cases. International Journal of Oral and Maxillofacial Surgery. 2017; 46: 1579–1583.
[77] Han ZX, Chen MJ, Yang C, Dong MJ. Recurrent synovial chondromatosis of the temporomandibular joint: report of two cases. British Journal of Oral and Maxillofacial Surgery. 2017; 55: 965–967.
[78] Kim DH, Lee EH, Cho ES, Kim JY, Jeon KJ, Kim J, et al. Temporomandibular joint synovial chondromatosis extending to the temporal bone: a report of two cases. Journal of the Korean Association of Oral and Maxillofacial Surgeons. 2017; 43: 336–342.
[79] Holtmann H, Böttinger T, Kübler NR, Singh DD, Sproll CK, Sander K, et al. Intra- and extracapsular synovial chondromatosis of the temporomandibular joint: rare case and review of the literature. SAGE Open Medical Case Reports. 2018; 6: 2050313X18775307.
[80] Kim HS, Lee W, Choi JW, Han WJ, Kim EK. Temporomandibular joint synovial chondromatosis accompanying temporal bone proliferation: a case report. Imaging Science in Dentistry. 2018; 48: 147–152.
[81] Singh K, Ghosh S, Verma M, Gupta S. Imaging findings in a case of synovial chondromatosis of temporomandibular joint. Journal of Indian Academy of Oral Medicine and Radiology. 2018; 30: 73–77.
[82] Romano A, Lo Faro C, Salzano G, Dell’aversana Orabona G, Petrocelli M, Corvino R, et al. Synovial chondromatosis of temporomandibular joint spreading into the cranial space. Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology. 2018; 30: 267–271.
[83] Vellone V, Bracciolini V, Ramieri V, Pernazza A, Della Rocca C, Cascone P. Synovial chondromatosis and calcium pyrophosphate deposition of the temporomandibular joint: challenging diagnosis. Journal of Craniofacial Surgery. 2018; 29: e792–e794.
[84] Mikami T, Kato Y, Kojima T, Abe T, Maruyama S, Nishiyama H, et al. An unusual and difficult diagnosis of synovial chondromatosis: a case report. Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology. 2018; 30: 422–427.
[85] Brabyn PJ, Capote A, Muñoz-Guerra MF, Zylberberg I, Rodríguez-Campo FJ, Naval-Gías L. Arthroscopic management of synovial chondromatosis of the temporomandibular joint. Case series and systematic review. Journal of Maxillofacial and Oral Surgery. 2018; 17: 401–409.
[86] Benslama L, Schouman T, Toure S, Chardain J, Goudot P. Synovial chondromatosis of the temporomandibular joint: report and analysis of 12 cases. Journal of Stomatology Oral and Maxillofacial Surgery. 2019; 120: 476–479.
[87] Lee LM, Zhu YM, Zhang DD, Deng YQ, Gu Y. Synovial chondromatosis of the temporomandibular joint: a clinical and arthroscopic study of 16 cases. Journal of Cranio-Maxillofacial Surgery. 2019; 47: 607–610.
[88] Maffia F, Vellone V, De Quarto C, Runci Anastasi M, Cascone P. Synovial chondromatosis of the temporomandibular joint with glenoid fossa erosion: disk preservation for spontaneous anatomical recovery. Journal of Cranio-Maxillofacial Surgery. 2019; 47: 1898–1902.
[89] Tang B, Wang K, Wang H, Zheng G. Radiological features of synovial chondromatosis affecting the temporomandibular joint: report of three cases. Oral Radiology. 2019; 35: 198–204.
[90] Liu X, Wan S, Shen P, Qiu Y, Sah MK, Abdelrehem A, et al. Diagnostic accuracy of synovial chondromatosis of the temporomandibular joint on magnetic resonance imaging. PLOS ONE. 2019; 14: e0209739.
[91] Matsuda S, Yoshimura H, Sano K. Application of a real-time 3-dimensional navigation system for treatment of synovial chondromatosis of the temporomandibular joint: a case report. Medicine. 2019; 98: e15382.
[92] Mathew P, Tiwari RVC, Govindan NO. Temporomandibular joint synovial chondromatosis posing as diagnostic dilemma: a case report. Journal of Maxillofacial and Oral Surgery. 2019; 18: 543–546.
[93] Barraclough O, Wilson G, Power A. Synovial chondromatosis of the temporomandibular joint: a case report. Annals of the Royal College of Surgeons of England. 2020; 102: e213–e215.
[94] Haapalainen L, Snäll J. Synovial chondromatosis of the temporomandibular joint: condyle osteotomy of the mandible and patient-specific fixation implant. British Journal of Oral and Maxillofacial Surgery. 2020; 58: e122–e123.
[95] Nath P, Menon S. Synovial chondromatosis of the temporomandibular joint. Journal of Maxillofacial and Oral Surgery. 2020; 19: 230–234.
[96] Gross AJ, Houston KR, Hudson JW, McCoy JM. A multidisciplinary approach to synovial chondromatosis of the temporomandibular joint with cranial base involvement: a brief review of the literature and case report. Journal of Oral and Maxillofacial Surgery. 2020; 78: 1759–1765.
[97] Morales RJ, Cabrales RA. Synovial chondromatosis affecting the temporomandibular joint: a case report and literature review. Oral and Maxillofacial Surgery Cases. 2020; 6: 100144.
[98] Barretto MDA, Kaba SCP, Elias FM, Deboni MCZ. Surgical treatment of a rare bilateral synovial chondromatosis. Autopsy and Case Reports. 2020; 10: e2020183.
[99] Yoshida H, Tsuji K, Ishikawa H, Nakayama M, Yamamoto M, Takasugi N, et al. Scanning electoronmicroscopical analysis of the loose bodies of synovial chondoromatosis in temporomandibular joint. Medical Molecular Morphology. 2020; 53: 82–85.
[100] Jang BG, Huh KH, Kang JH, Kim JE, Yi WJ, Heo MS, et al. Imaging features of synovial chondromatosis of the temporomandibular joint: a report of 34 cases. Clinical Radiology. 2021; 76: 627.e1–627.e11.
[101] Zhao W, Ruan Y, Zhang W, Yang F. Synovial chondromatosis of the temporomandibular joint with 400 loose bodies: a case report and literature review. Journal of International Medical Research. 2021; 49: 3000605211000526.
[102] Yoshitake H, Kayamori K, Wake S, Sugiyama K, Yoda T. Biomarker expression related to chondromatosis in the temporomandibular joint. CRANIO®. 2021; 39: 362–366.
[103] Nishiyama M, Nozawa M, Ogi N, Ariji Y, Fukuda M, Kise Y, et al. Computed tomographic features of synovial chondromatosis of the temporomandibular joint with a few small calcified loose bodies. Oral Radiology. 2021; 37: 236–244.
[104] Destruhaut F, Dubuc A, Bos A, Fabié L, Pomar P, Combadazou JC, et al. Diagnosis of synovial chondromatosis of temporomandibular joint: case report and literature review. Healthcare. 2021; 9: 601.
[105] Durna D, Çakur B, Bayındır N. Temporomandibular joint synovial chondromatosis: a rare case. Cumhuriyet Dental Journal. 2021; 24: 281–285.
[106] Cameron A, Richards C, Keating CJ, Colbert SD. Three dimensional reconstruction imaging of temporomandibular joint synovial chondromatosis. Oral Surgery. 2021; 14: 236–240.
[107] Matsusue Y, Yamamoto K, Yamakawa N, Yamamoto I, Matsuda S, Yoshimura H, et al. A case of synovial chondromatosis of temporomandibular joint with numerous loose bodies. Case Reports in Dentistry. 2021; 2021: 5927215.
[108] Fukutani T, Toratani S, Kanda T, Matsui K, Yamasaki S, Sumi K, et al. Two cases of temporomandibular synovial chondromatosis associated with Gli1 gene mutation. International Journal of Environmental Research and Public Health. 2022; 19: 4702.
[109] Satyanarayan P, Roy ID, Issar Y, Tomar K, Jakka S. Comparative evaluation of success in cases of synovial chondromatosis of temporomandibular joint treated with temporomandibular joint arthroscopy: a case series. Journal of Maxillofacial and Oral Surgery. 2022; 21: 1227–1232.
[110] Jia M, Xu Y, Shao B, Guo Z, Hu L, Pataer P, et al. Diagnostic magnetic resonance imaging in synovial chondromatosis of the temporomandibular joint. British Journal of Oral and Maxillofacial Surgery. 2022; 60: 140–144.
[111] Nashi M, Yamamoto S, Maeda K, Taniike N, Hara S, Takenobu T. A case of deposition of calcium pyrophosphate dehydrate crystals with synovial chondromatosis in the temporomandibular joint. Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology. 2021; 34: 49–54.
[112] Murahashi M, Ntege EH, Higa M, Maruyama N, Kawano T, Shimizu Y, et al. Management of temporomandibular joint diseases: a rare case report of coexisting calcium pyrophosphate crystal deposition and synovial chondromatosis. BMC Oral Health. 2022; 22: 662.
[113] Song Z, Yuan S, Liu J, Bakker AD, Klein-Nulend J, Pathak JL, et al. Temporomandibular joint synovial chondromatosis: an analysis of 7 cases and literature review. Science Progress. 2022; 105: 368504221115232.
[114] Burris B, Guastaldi FPS, Hadad H, Faquin WC, McCain JP. Arthroscopic management of synovial chondromatosis with skull base perforation: a case report and literature review. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 2023; 136: e1–e10.
[115] Han W, Luo H, Zhao Y, He Z, Guo C, Meng J. Retrospective study of synovial chondromatosis of the temporomandibular joint: clinical and histopathologic analysis and the early-stage imaging features. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 2024; 137: 215–223.
[116] Kaneko I, Karino M, Osako-Sonoyama R, Ishizuka S, Toda E, Kanayama J, et al. A rare case of facial asymmetry caused by simultaneous development of osteochondroma and synovial chondromatosis at the temporomandibular joint. Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology. 2023; 35: 147–152.
[117] Jenzer AC, Trotta R, Hechler BL, Powers DB. Synovial chondromatosis: a case series and review of the literature. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 2023; 136: 276–283.
[118] Machado GG, Zambon CE, de Lima JMDS, Paiva GLA, Martins VAO, Peres MPSM. Synovial chondromatosis of the temporomandibular joint-clinical, surgical, and imaging findings of a Milgram stage III case series. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 2023; 135: e94–e101.
[119] Cini MA, Avelino MD, Machado JG, Junior RL, Santos AV. Chondromatosis of the temporomandibular joint as a cause of reflex otalgia. Brazilian Journal of Otorhinolaryngology. 2023; 89: 101284.
[120] Morishima H, Nogami S, Igarashi A, Imoto K, Saito S, Chiba M, et al. A case of tenosinovial giant cell tumor secondary to synovial chondromatosis in the temporomandibular joint. Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology. 2023; 35: 572–576.
[121] Jang BG, Huh KH, Yeom HG, Kang JH, Kim JE, Yoon HJ, et al. Differentiation between chondrosarcoma and synovial chondromatosis of the temporomandibular joint using CT and MR imaging. American Journal of Neuroradiology. 2023; 44: 1176–1183.
[122] Sembronio S, Raccampo L, Tel A, Di Cosola M, Troise S, Dell’Aversana Orabona G, et al. The role of temporomandibular joint arthroscopy for diagnosis and surgical management of synovial chondromatosis. Diagnostics. 2023; 13: 2837.
[123] Zhang Y, Yu F, Long X, Fang W. Imaging features of temporomandibular joint synovial chondromatosis with associated osseous degenerative changes. International Journal of Oral and Maxillofacial Surgery. 2024; 53: 311–318.
[124] Vladimír M, Vasilis V, Dušan H, Robert P, Michal B, René F. TMJ synovial chondromatosis—an evaluation of 37 patients. Oral and Maxillofacial Surgery. 2024; 28: 1653–1660.
[125] Spallaccia F, De Tomaso S, Picotti A, Vellone V. The role of PETRA MRI sequences in the diagnosis of chondromatosis of the temporomandibular joint with erosion of the glenoid fossa. International Journal of Oral and Maxillofacial Surgery. 2024; 53: 1015–1018.
[126] Neumann JA, Garrigues GE, Brigman BE, Eward WC. Synovial chondromatosis. JBJS Reviews. 2016; 4: e2.
[127] Murad MH, Sultan S, Haffar S, Bazerbachi F. Methodological quality and synthesis of case series and case reports. BMJ Evidence-Based Medicine. 2018; 23: 60–63.
[128] de Almeida Hoff E, Grossi RK, Bozzetti Pigozzi L, Bueno CH, Pattussi MP, Rossi T, et al. Depression and the risk of developing temporomandibular disorders in different diagnostic groups: a systematic review with meta-analysis. CRANIO®. 2025; 43: 730–742.
[129] Uehara LM, Tardelli JDC, Botelho AL, Valente MLDC, Dos Reis AC. Association between depression and temporomandibular dysfunction in adults—a systematic review. CRANIO®. 2025; 43: 461–467.
[130] Manfredini A, Saracutu OI, Greene CS, Ferrari M, Manfredini D. Patient experiences with temporomandibular disorders: a survey on the pathways in diagnosis and treatment. Journal of Oral Rehabilitation. 2025; 52: 1481–1488.
[131] Marpaung C, Yap AU, Hanin I, Fitryanur A. Psychological distress and well-being: their association with temporomandibular disorder symptoms. CRANIO®. 2024; 42: 285–291.
[132] Oliveira-Souza AIS, Sales LRDV, Coutinho ADF, Armijo Olivo S, de Oliveira DA. Oral health quality of life is associated to jaw function and depression in patients with myogenous temporomandibular dysfunction. CRANIO®. 2023; 41: 518–528.
[133] Yap AU, Wee KK, Loh JY, Marpaung C, Natu VP. Temporomandibular disorder pain in older adolescents-young adults: interrelationship with somatic burden, mental ill-being, and well-being. CRANIO®. 2025; 43: 719–729.
[134] Colonna A, Guarda-Nardini L, Ferrari M, Manfredini D. COVID-19 pandemic and the psyche, bruxism, temporomandibular disorders triangle. CRANIO®. 2024; 42: 429–434.
[135] Saracutu OI, Manfredini D, Bracci A, Ferrari Cagidiaco E, Ferrari M, Colonna A. Self-reported mandible bracing and teeth clenching are associated with anxiety and depression traits in a group of healthy young individuals. Journal of Oral & Facial Pain and Headache. 2024; 38: 85–90.
[136[ Yap AU, Peng BMH, Lim SY, Lee DZR. Association of temporomandibular disorders severity with otologic and concomitant pain symptoms in Asian youths. CRANIO®. 2025; 43: 128–134.
[137] Manfredini D, Häggman-Henrikson B, AI Jaghsi A, Baad-Hansen L, Beecroft E, Bijelic T, et al. Temporomandibular disorders: INfORM/IADR key points for good clinical practice based on standard of care. CRANIO®. 2025; 43: 1–5.
[138] Val M, Ragazzo M, Colonna A, Ferrari M, Ferrari Cagidiaco E, Manfredini D, et al. Pseudogout of the temporomandibular joint: a case report with systematic literature review. Journal of Oral & Facial Pain and Headache. 2025; 39: 49–69.
[139] Pehlivan Tekin G, Yakut Y. Effectiveness of a home exercise program when added to a conventional physiotherapy program in patients with temporomandibular disorders: a comparative study. CRANIO®. 2025; 43: 851–862.
[140] Liu S, Cai B, Fan S, Zhang Y, Lu S, Xu L. Effects of patient education on the oral behavior of patients with temporomandibular degenerative joint disease: a prospective case series study. CRANIO®. 2025; 43: 100–109.
[141] Naderi Y, Karami E, Chamani G, Amizadeh M, Rad M, Shabani M. Temporomandibular treatments are significantly efficient in improving otologic symptoms. BMC Oral Health. 2023; 23: 913.
[142] Melo RA, de Resende CMBM, Rêgo CRF, Bispo ASL, Barbosa GAS, de Almeida EO. Conservative therapies to treat pain and anxiety associated with temporomandibular disorders: a randomized clinical trial. International Dental Journal. 2020; 70: 245–253.
[143] Tanhan A, Ozer AY, Polat MG. Efficacy of different combinations of physiotherapy techniques compared to exercise and patient education in temporomandibular disorders: a randomized controlled study. CRANIO®. 2023; 41: 389–401.
[144] Dao TT, Lavigne G. Oral splints: the crutches for temporomandibular disorders and bruxism? Critical Reviews in Oral Biology & Medicine. 1998; 9: 345–361.
[145] Andre A, Kang J, Dym H. Pharmacologic treatment for temporomandibular and temporomandibular joint disorders. Oral and Maxillofacial Surgery Clinics of North America. 2022; 34: 49–59.
Science Citation Index (SCI)
Science Citation Index Expanded (SCIE)
BIOSIS Previews
Scopus: CiteScore 3.1 (2024)
Cumulative Index to Nursing and Allied Health Literature (CINAHL)
Top