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Modern Concepts and Evidence Base in Trigeminal Neuralgia
Deadline for manuscript submissions: 31 August 2026
Print Special Issue Flyer (8)Special Issue Editor
Guest Editor
Prof. Andrei Brinzeu, MD, PhDE-MailWebsite
Timisoara Neuroscience Research Center, Universitatea de Medicina si Farmacie Victor Babes, Timisoara, Romania
Interests: Trigeminal Neuralgia; Functional Neurosurgery; Brain Tumor Surgery
Guest Editor
Asst. Prof. Cristian Son, MScE-MailWebsite
Timisoara Neuroscience Research Center, Universitatea de Medicina si Farmacie Victor Babes, Timisoara, Romania
Interests: Trigeminal Neuralgia
Special Issue Information
The understanding of trigeminal neuralgia has undergone a remarkable refinement in recent years. Central to this evolution is the reclassification of TN subtypes based on etiology: Classical trigeminal neuralgia—now firmly defined as neuralgia due to vascular compression of the trigeminal nerve—has been distinguished from secondary forms caused by other pathology, and from idiopathic forms likely rooted in genetic or intrinsic factors. This clear etiological framework, grounded in robust clinical, imaging, and pathophysiological evidence, is transforming patient care through more precise diagnosis and targeted treatment strategies.
Building on this foundation, in this special issue, we welcome reviews and original research addressing two synergistic domains:1） Clinical innovations— including microvascular decompression, radiofrequency thermocoagulation, and radiosurgery— implemented with rigorous diagnostic criteria; and 2) Mechanistic explorations— studies exploring the fundamental mechanisms of trigeminal neuralgia, such as spanning demyelination dynamics, ion channelopathies, and neuroimmune cross-talk— that elucidate fundamental pain pathways and treatment resistance.
Through this special issue, we aim to consolidate the modern evidence base, bridging mechanistic insights with therapeutic advances. Contributions addressing diagnostic challenges in atypical presentations or predictors of treatment response are particularly encouraged. Whether reinforcing or challenging current paradigms, these contributions aim to advance both our scientific understanding and our clinical practice in this evolving field.
Keywords
Trigeminal Nerualgia; Neruovascular Conflict; Microvascular decompression; Radiofrequency thermorhizotomy; balloon compression; Radiosurgery; Evidence Based Medicine
Manuscript Submission Information
Manuscripts should be submitted online by submit system. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Original articles, case reports or comprehensive reviews are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website. Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Oral & Facial Pain and Headache is an international peer-reviewed open access journal published by MRE Press. Please visit the Instructions for Authors page before submitting a manuscript.The Article Processing Charge (APC) for publication in this open access journal is $2500. We normally offer a discount greater than 30% to all contributors invited by the Editor-in-Chief, Guest Editor (GE) and Editorial board member. Submitted papers should be well formatted and use good English.
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